Catalog
- Results include
-
-
Cell death
San Diego : Academic Press, c1995."Cell Death" provides a comprehensive collection of methods for the study of cell death. Using a diverse range of technical approaches and model systems, the chapters in this volume cover topics from the cellular and organismal to the molecular and anatomical. In the tradition of this long-standing series, this volume's user-friendly recipes and more 100 tables and figures make the study of cell death accessible across life science disciplines. Because of breakthroughs such as the "switching" mechanism of the p53 tumour suppressor gene, as well as many technical innovations, the number of investigators of cell death has rapidly expanded over the last few years. Students of apoptosis and other types of cell death hypothesise that virtually all cells are genetically programmed to self-destruct. In turn, they also have learned that massive cell death does not always represent pathology, but rather a normal and necessary "weeding out" in the development and life of an organism. The clinical implications are immense, as the understanding and ability to regulate this process may offer the potential to treat cancer and a wide variety of other disorders. KEY FEATURES: A cross-disciplinary look at cell death using a broad range of technical approaches and model systems; The protocols and insights presented are the products of years of study by experts in their fields; The chapters cover a topical spectrum from the cellular to the organismal and the molecular to the anatomical; The methods are illustrated with user-friendly recipes and more than 100 tables, halftones, and diagrams; The techniques described facilitate both understanding and regulation of cell death, promising to have immense value in the clinical treatment of cancer; Illustrated with colour plates.
-
Cell death : mechanism and disease
New York, NY : Springer, 2014.Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response.?When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!
Online SpringerLink
Your search also found 1 topic specific databases.
Guides
Library website
Exhibits
EarthWorks
More search tools
Tools to help you discover resources at Stanford and beyond.
