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  1. Mechanisms in the pathogenesis of enteric diseases

    New York : Springer Science+Business Media, LLC, [1997]

    The topics include the epidemiology and pathobiology of enteric diseases, mechanisms of identity and interaction between host and pathogen, effector mechanisms in the pathogenesis and regulation of pathogenic activity in enteric diseases, and novel approaches to the prevention and therapy of enteric diseases. Diarrheal diseases caused by bacteria, viruses, and protozoa are among the most common diseases of animals and humans. They have also been among the most resistant diseases to prevent. Progress in the management of one disease is frequently overshadowed by the emergence of a new, more challenging enteric disease problem. The zoonotic character of many enteric pathogens links veterinary and medical concerns. At least five enteropathogens, Campylobacter jejuni, non-typhoid Salmonella, Escherichia coli O157:H7, Clostridium perfringens, and Cryptosporidium parvum, shed in the feces of pigs, cattle, and/or poultry, are important causes of diarrhea in human beings. Substantial progress in the control of enteric pathogens will require greater understanding of the mechanisms by which these organisms cause disease, elucidation of environments that favor their proliferation, and clarification of natural host defenses against them. The advances in knowledge presented here will help lead to the development of novel and innovative approaches to prevention and therapy, as well as to improvements to conventional treatments.This book, Mechanisms in the Pathogenesis of Enteric Diseases, is the outcome of the First International Rushmore Conference on Mechanisms in the Pathogenesis of En- teric Diseases, held in September 1995 at Rapid City, South Dakota. The meeting was or- ganized by members of the North-Central Regional Research Committee "NC-62, " a United States Department of Agriculture-sponsored consortium of swine enteric disease researchers from land-grant institutions. This conference was conceived as a forum for an interdisciplinary discussion of mechanisms of infectious diseases. It was intended that such a discussion would stimulate cross-fostering of ideas and nurture synergistic collabo- rations among scientists working on enteric diseases of humans and animals_. In atten- dance, there were more than 140 participants from the United States and 12 foreign countries representing all of the world's continents. Participants brought expertise from many disciplines in both human and veterinary medicine. Multiple perspectives and an in- formal atmosphere provided an environment for lively and thought-provoking discussions. Conference topics included Pathobiology of Gastroenteric Diseases, Mechanisms of Iden- tity and Interaction between Host and Pathogen, Effector Mechanisms in the Pathogenesis of Enteric Diseases, Regulation of Pathogenic Activity in Enteric Diseases, and Novel Ap- proaches to Prevention and Therapy of Enteric Diseases. Ten internationally renowned scientists gave keynote presentations in addition to 30 oral presentations and 39 poster presentations. The keynote speakers were Drs.

    Online SpringerLink

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