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Computationally guided drug repurposing as a drug development strategy [electronic resource]

The pharmaceutical industry is experiencing unprecedented financial pressures and unsustainable research expenditures, threatening to compromise the robust development of new therapies. In response many pharmaceutical companies and translational research organizations have invested heavily in new technologies promising more efficient and productive research, including high-throughput screening, combinatorial chemistry for compound library generation, genetics and pharmacokinetics, and many others. Unfortunately these technologies have largely failed to significantly increase the efficiency of pharmaceutical research, as evidenced by the steady increase in research dollars required per new approved drug (currently estimated at nearly