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Protein refolding

Online ACS Publications

Old and new views of protein folding : proceedings of the 24th Taniguchi International Symposium, Division of Biophysics, held in Kisarazu, 3-7 March 1999

Elucidation of protein folding mechanisms is a fundamental problem of molecular biological physics. During the last several years, remarkable advances have been made in this field. Experimentally, folding intermediates have been characterized in detail using various new techniques, and certain small proteins are found to fold in a two-state manner. Theoretical studies of simple model proteins have put forward new ideas of folding, and recent progress in computational techniques has made unfolding/folding simulations very realistic. These advances have allowed us to describe the protein folding in a precise manner, but our questions of how a protein folds into its specific native structure have become more hotly debated. "Old views" are often being challenged by "new views." We have reached a very exciting stage of the protein folding studies, and combination of the experimental and theoretical studies is indispensable for further clarification of the folding problem. This book thus describes the recent advances in the following topics: kinetic folding mechanisms, characterization of folding intermediates, fast folding reactions, structural stability of proteins, theory of protein folding, computer simulations, and molecular evolution in relation to protein folding. This book will appeal to researchers and graduate students of biophysics, biochemistry and molecular biology.

Protein folding : in vivo and in vitro

Covers the most recent advances in the field of protein folding and its impact on future technologies. Reviews in vivo aspects such as mechanisms of inclusion body formation and molecular chaperones, and includes highlights of Jonathan King's work at MIT. In vitro aspects examined include methods of protein folding, recovery of commercial protein products, and genetic approaches to understanding and solving protein folding problems. Written by leading scientists in the field, the volume provides a linkage between fundamental academic research and industrial applications of protein folding technology.

Online ACS Publications