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Epigenetic regulation of olfactory receptor gene expression by the Drosophila Myb-MuvB/dREAM complex [electronic resource]
Sim, Choon Kiat2012.In both mammals and insects an olfactory neuron will usually select a single olfactory receptor and repress remaining members of large receptor families. Here we show that a conserved multiprotein complex Myb-MuvB(MMB)/dREAM plays an important role in mediating neuron-specific expression of the CO2 receptor genes (Gr63a/Gr21a) in Drosophila. Activity of Myb in the complex is required for expression of Gr63a/Gr21a and it acts in opposition to the histone methyltransferase Su(var)3-9. Consistent with this, we observe repressive di-methylated H3K9 modifications at the receptor gene loci suggesting a mechanism for silencing receptor gene expression. Conversely, other complex members, Mip120 and E2F2, are required for repression of Gr63a in inappropriate neurons. Misexpression in mutants is accompanied by an increase in the H3K4me3 mark of active chromatin at the receptor gene locus. Nuclei of CO2 receptor-expressing neurons contain reduced levels of the repressive subunit Mip120 compared to surrounding neurons and increased levels of Myb, suggesting that activity of the complex can be regulated in a cell-specific manner. Our evidence suggests a model in which olfactory receptors are regulated epigenetically and the MMB/dREAM complex plays a critical role in specifying, maintaining and modulating the receptor-to-neuron map.
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High school for all in East Asia : comparing experiences
Abingdon, Oxon ; New York, NY : Routledge, 2019."Although late to industrialize, East Asia has witnessed rapid development whilst maintaining some of the highest educational enrollment rates and indicators of academic achievement globally. From major players, such as China, to small city-states, such as Singapore, economic success and the growth of education have seemingly unfolded simultaneously. This book therefore seeks to better understand the relationship between these powerful economies and their commitment to educational expansion. Exploring the universalization of upper secondary schooling, it assesses the social foundations of the region's economic development. Chapters covering each of the countries of East Asia trace how upper secondary school functions as the support for the mass manufacturing labor force, which has been instrumental in East Asian economic expansion. These analyses then compare the experiences of the different nations along two major axes: the relationship between public and private provision and the balance between general and vocational tracks. Finally, this book goes onto examine recent trends, including the slowing of social development and declining fertility, and ultimately asks, can East Asia maintain its world leading development and educational standards? Combining a wealth of quantitative data and policy analyses, this book will be useful to students and scholars of Asian and international education"--Although late to industrialize, East Asia has witnessed rapid development whilst maintaining some of the highest educational enrollment rates and indicators of academic achievement globally. From major players, such as China, to small city-states, such as Singapore, economic success and the growth of education have seemingly unfolded simultaneously. This book seeks to better understand the relationship between these powerful economies and their commitment to educational expansion. Exploring the universalization of upper secondary schooling, it assesses the social foundations of the region's economic development. Chapters covering each of the countries of East Asia trace how upper secondary school functions as the support for the mass manufacturing labor force, which has been instrumental in East Asian economic expansion. These analyses then compare the experiences of the different nations along two major axes: the relationship between public and private provision and the balance between general and vocational tracks. Finally, the analyses go on to examine recent trends, including the slowing of social development and declining fertility, and ultimately asks, can East Asia maintain its world leading development and educational standards in coming decades? Combining a wealth of quantitative data and policy analyses, this book will be useful to students and scholars of Asian and international education.
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