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1. Mass spectrometry : principles and applications

   Hoffmann, Edmond de.

   2nd ed. / Edmond de Hoffmann, Vincent Stroobant. - Chichester ; New York : Wiley, c2001.

   This work offers a complete overview of the principles, theories and key applications of modern mass spectrometry in this introductory textbook. Following on from the highly successful first edition, this edition is extensively updated including new techniques and applications. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Revised and updated numerous examples and illustrations are combined with a series of exercises to help encourage student understanding. It includes biological applications, which have been significantly expanded and updated. It also includes coverage of ESI and MALDI.

2. Mass spectrometry : principles and applications

   Hoffmann, Edmond de.

   Chichester ; New York : Wiley ; Paris : Masson, c1996.

   This is an introductory book aimed at students, technicians and practising analytical scientists in the chemical, biological and biochemical sciences. It introduces the reader to the basics of mass spectrometry, but also contains coverage of many important modern techniques, such as electrospray ionization and matrix assisted laser desorption ionisation, and of modern instrumentation. It contains guidance for the investigator who wishes to undertake investigations in the fields of (I) applications of mass spectrometry to biological molecules (II) analysis of complex mixtures and (III) analysis of samples that require derivationization, chromatography and/or tandem analysis.Mass Spectrometry Principles and Applications Edmond De Hoffmann Jean Charette Vincent Stroobant Universite catholique de Louvain, Belgium Mass spectrometry is a technique widely used throughout science for the identification of compounds, by producing, separating and detecting ions in the gas phase. A complete overview of the principles, theories and key applications of modern mass spectrometry are presented in this carefully structured text. All instrumental aspects of mass spectrometry are clearly and concisely described; sources, analysers and detectors. Tandem mass spectrometry is introduced early, and then developed in more detail in its own chapter. Emphasis is placed throughout the text on optimal utilization conditions. Various fragmentation patterns are described, along with the analytical information that derives from the mass spectra. The importance of applications is recognized, and this theme runs throughout the book, along with an entire chapter devoted to the analysis of biomolecules. Numerous examples and illustrations feature throughout, along with a series of exercises of increasing difficulty that help students fully to understand the subject. References to the original literature are provided for the reader who wants more detailed information, along with a list of books for further reading. Mass Spectrometry will be invaluable to undergraduates and postgraduates using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture and food science. It will also appeal to researchers looking for an introduction to this important technique. The authors . have chosen a level of presentation that will be useful to . students as a text and valuable to practitioners as a handbook. They have produced an entirely modern treatment which seems to be just right in its coverage of the underlying physical principles, the instrumentation and techniques, and the applications. They have taken the trouble to give their readers clear, well-chosen figures. The text is comprehensive without being encyclopaedic and should be very readable by people in a variety of disciplines. The weight given to modern biological applications is one of the strong points of the book; these are discussed in the context of the underlying chemistry. Professor R. Graham Cooks, Purdue University, USA This book provides an excellent coverage of all the main aspects of modern mass spectrometry. As such it will be a valuable text for students throughout all stages of their training - from first year BSc to final year PhD. Professor John Todd, University of Kent at Canterbury, UK.

3. Mass spectrometry : principles and applications

   Hoffmann, Edmond de.

   3rd ed. - Chichester, West Sussex, England ; Hoboken, NJ : J. Wiley, c2007.

   The latest edition of a highly successful textbook, "Mass Spectrometry, Third Edition" provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. "Mass Spectrometry, Third Edition" is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

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